1
to use completely;to use up;to exhaust
毎晩飲み歩いてばかりいたら、奥さんに愛想尽かされるぞ。
If you stay out drinking every night, your wife is going to leave you.
2
to exhaust someone's civility;to give up (on someone)
See also:
愛想を尽かす (あいそをつかす)